Oregon Grape Root is a shrub that is usually found in California, Idaho, Washington, and British Columbia. The plant has green leaves that turn purple in the winter. In other seasons, the plant has yellow flowers and produces purple berries. Also known as Berberis Aquifolium, it contains an alkaloid substance called Berberine. This substance has been used for many years in Ayurveda, Chinese medicine and in weight loss supplements. Let’s dive in deeper to know more about Oregon Grape Root!
How to Use Oregon Grape Root
The bark or root of the Oregon Grape Root is used in herbal medicine. The plant is most potent when its color is a vibrant yellow. Berberine present in Oregon Grape Root may have anti-inflammatory and antidepressant properties (1, 2). It may also help in a series of other conditions which are further discussed later in this article.
Benefits of Oregon Grape Root
Oregon Grape Root May Act As An Antidepressant
Berberine present in Oregon Grape Root may help reduce the symptoms of depression by increasing neurotransmitters in the cortex of the brain (3, 4). A recent study has revealed that Berberine assists in controlling depression and anxiety (5). Overall, it does seem like the Berberine present in this herb may be used to help alleviate the symptoms of depression.
Effects Of Oregon Grape Root On Blood Sugar Levels
Oregon Grape Root has been shown to have a positive effect on blood sugar levels as it may help keep blood sugar levels from spiking. This root assists in managing symptoms of fasting sugar and cholesterol levels, which may help the body tolerate glucose (6, 7, and 8).
Accelerates Weight Loss
The Berberine content in Oregon Grape Root helps restrict the storage of fat, which may help show an improvement in the body’s insulin activity (9). The herb also has inhibitors like CHOP and DEC2 which may help slow down the production of fat in the body. In a recent study, obese patients were given Berberine three times a day for a period of 12 weeks. This led to an average weight loss of at least 5 pounds (10). Due to its ability to help people lose weight, Oregon Grape Root is commonly used in various weight loss supplements.
Helps In Detoxification
Oregon Grape Root is used in fat loss supplements and formulas because it has antimicrobial properties. It is known to stimulate bile flow and has been used to address the symptoms of other liver conditions as well (11). Oregon Grape Root is used in many liquid detox formulas as well. The SuperFood WeightLoss Accelerator Program includes the Total Cleanse formula which contains this wonderful herb. Total Cleanse may help cleanse the lymphatic system, eliminate toxins, purify the bloodstream and support healthy yeast cells. The other formulas of the program, Mega Minerals, Sea Vegetables, and Will Power, may help curb hunger, accelerate weight loss and boost metabolism.
Improves Gut Activity
Berberine may be helpful in reducing symptoms of diarrhea (12, 13). It protects the lining of
the gut and may help you avoid Leaky Gut Syndrome (14). A research study proved that Oregon Grape Root assists in neutralizing gut bacteria which may help improve the effects of the fatty liver disease in mice (15).
However, before introducing Oregon Grape Root or its supplements to your diet, it is best that you consult your physician.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The statements and/or product(s) described in this article are not intended to diagnose, treat, cure, mitigate or prevent any disease, illness or health condition. It is advisable to consult your healthcare provider before making any changes to your lifestyle, diet or dietary supplement program.
- Sci Rep. 2016 Mar 3;6:22612. doi: 10.1038/srep22612.Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity.Guo T1, Woo SL1, Guo X1, Li H1, Zheng J1,2, Botchlett R1, Liu M1, Pei Y1, Xu H1, Cai Y1,2, Zeng T2, Chen L2, Li X3, Li Q4, Xiao X4,5, Huo Y6,7, Wu C1.https://www.ncbi.nlm.nih.gov/pubmed/26936230
- Send to Korean J Physiol Pharmacol. 2012 Dec;16(6):379-86. doi: 10.4196/kjpp.2012.16.6.379. Epub 2012 Dec 10.Effect of berberine on depression- and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in rats.Lee B1, Sur B, Yeom M, Shim I, Lee H, Hahm DH.https://www.ncbi.nlm.nih.gov/pubmed/23269899
- Eur J Pharmacol. 2008 Jul 28;589(1-3):163-72. doi: 10.1016/j.ejphar.2008.05.043. Epub 2008 Jun 3.On the mechanism of antidepressant-like action of berberine chloride.Kulkarni SK1, Dhir A.https://www.ncbi.nlm.nih.gov/pubmed/18585703
- Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in miceAuthor links open overlay panelWen-HuangPengaKuan-LinLoaYi-HsuenLeeaTai-HuangHungbYing-ChihLinchttps://www.sciencedirect.com/science/article/pii/S0024320507005796
- Planta Med. 2001 Feb;67(1):74-6.Monoamine oxidase inhibitors from rhizoma of Coptis chinensis.Kong LD, Cheng CH, Tan RX.https://www.ncbi.nlm.nih.gov/pubmed/11270727
- Acta Pharmacol Sin. 2004 Apr;25(4):496-502.Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion.Leng SH1, Lu FE, Xu LJ.https://www.ncbi.nlm.nih.gov/pubmed/15066220
- Efficacy of Berberine in Patients with Type 2 DiabetesJun Yin,a,b,* Huili Xing,a and Jianping Yehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/
- J Clin Endocrinol Metab. 2008 Jul;93(7):2559-65. doi: 10.1210/jc.2007-2404. Epub 2008 Apr 8.Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.Zhang Y1, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning G.https://www.ncbi.nlm.nih.gov/pubmed/18397984
- Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients.Yang J1, Yin J, Gao H, Xu L, Wang Y, Xu L, Li M.https://www.ncbi.nlm.nih.gov/pubmed/22474499
- Berberine Improves Insulin Sensitivity by Inhibiting Fat Store and Adjusting Adipokines Profile in Human Preadipocytes and Metabolic Syndrome PatientsJing Yang, 1 Jinhua Yin, 1 , 2 Hongfei Gao, 1 Linxin Xu, 1 , 2 Yan Wang, 1 Lu Xu, 2 and Ming Li 2 ,*Author information ► Article notes ► Copyright and License information ► Disclaimerhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310165/
- [Effect of berberine on transit time of human small intestine].[Article in Chinese]Yuan J1, Shen XZ, Zhu XS.https://www.ncbi.nlm.nih.gov/pubmed/7719104
- Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins.Sack RB, Froehlich JL.https://www.ncbi.nlm.nih.gov/pubmed/7035365.J Infect Dis. 2011 Jun 1;203(11):1602-12. doi: 10.1093/infdis/jir147.
- Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia.Gu L1, Li N, Gong J, Li Q, Zhu W, Li J.https://www.ncbi.nlm.nih.gov/pubmed/21592990Arch Iran Med. 2016 Mar;19(3):197-203. doi: 0161903/AIM.008.
- Modulation of Gut Microbiota by Berberine Improves Steatohepatitis in High-Fat Diet-Fed BALB/C Mice.Cao Y1, Pan Q2, Cai W3, Shen F2, Chen GY2, Xu LM4, Fan JG5.https://www.ncbi.nlm.nih.gov/pubmed/26923892